• Price : $102.00


    The importance of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much more than their natural, youthful appearance. People also lose their self-esteem and self-confidence associated with healthy looking hair. Hair loss also, called alopecia, is a common problem a~ecting both men and women.

    Normal hair follicle is surrounded by healthy connective tissue and dermal papilla, and hasminimalorabsenceofinflammationnoroxidativestress.Hairlosssu~ererswillmost of the time have the hair growth cycle disrupted by an increase of dihydrotestosterone (DHT) hormone, loss of connective tissue integrity surrounding the hair follicle, and an increase of the inflammatory process and oxidative stress in the scalp. With age, the decrease number and size of hair follicles in the scalp will also lead to thinner hair and an increase in hair loss.


    HRS-1 0 is a biomimetic peptide (acetyl tetrapeptide-3) combined with a red clover extractrichinBiochaninA.HRS-1 0 efficacyisbasedontheassociationandsynergistic action of its two ingredients.

    HRS-1 0 has a direct action on 5-á-reductase which modulates dihydrotestosterone (DHT) to help prevent hair miniaturization. It improves ECM proteins integrity in dermal papilla for a better hair anchoring and reduces damages caused by inflammation, providing fuller, thicker and healthier looking hair.


    Inflammation reduction

    IL-1á mimics the inflamation process in human fibroblasts and induces IL-8, a pro-inflamatory cytokine.

    HRS-10 helps decrease pro-inflammatory cytokines with a synergistic action compared to red clover extract alone.

    DHT modulation via 5- á-red uctase activity

    DHT is formed by the action of 5- á-reductase on testosterone. DHT causes hair loss by shortening the growth cycle, producing progressively shorter and finer hair. This is the study of the capacity of Biochanin A to inhibit the 5-á reductase activity in comparison with a well known 5-á reductase inhibitor EGCG (epigallocatechin gallate a potent antioxidant found in tea).

    Biochanin A inhibits 5- -reductase activity.

    ECM renewal and anchoring improvement

    Hair follicles size is determined by:

    - T he volume of its dermal papilla;

    - T he volume of the extracellular matrix.

    Healthy dermal papilla will produce good ECM proteins such as collagen type III and anchoring fibers such as laminin and collagen VII which will favor a good hair anchoring in the bulb surrounding tissue. If improper ECM renewal, hair will eventually lack vigor and will thin. Cycle after cycle, the follicle becomes smaller and finally, miniaturized and fall.

    Prolineisanaminoacidconstituentofcollagen,thereforeitrepresentsagoodindication of newly synthesized collagen.

    Acetyl tetrapeptide-3 stimulates collagen production for better ECM integrity leading to a better anchoring.

    Quantification of laminin, type III collagen synthesis induced by Acetyl tetrapeptide-3 onfibroblasts.Ithasbeendemonstratedthatmoleculeswhichhaveanactivityonthese ECM proteins stimulation, also increase hair follicle size and improve hair anchoring.

    Human hair follicles in anagen phase are isolated from skin biopsys and cultured with or without Acetyl tetrapeptide-3 for 8 days.

    Acetyl tetrapeptide-3 improves by 35% the length in comparison with untreated areas after 8 days of treatment.


    Test protocol

    - 30 men with androgenetic alopecia: 15 treated with the HRS-10 lotion (5%) and 15 with a placebo.

    - Daily application of 20 drops of the HRS-1 0 lotion or placebo for a period of 4 months. - A digital trichogram (TrichoScan professional) was taken at D0 and 4 months later.

    HRS-10 induces a visible increase in the anagen hair density in comparison with placebo.

    HRS-10 induces a strong reduction in the telogen hair density in comparison with placebo.